The discomfort in women with endometriosis is painful. It causes inflammation and tissue growth on the outside of the uterus. It’s not just painful. It can also lead to complications with getting pregnant.
Endometriosis is typically treated with hormones and invasive surgery. However, it is a treatment of the symptoms. For patients who suffer continued growth from endometriosis, having multiple hysterectomies or laparoscopy surgeries can be stressful and costly. New studies show that there may be a way to achieve the same results without invasive methods.
What is Endometriosis
Endometriosis is a common condition in women ages 18-35. It is a tissue disorder in the uterus that causes tissue similar to the inner lining of the uterus to grow on the outside. It can become painful and cause irregular menstrual cycles.
Neuropeptide S Receptor 1 (NPSR1)
A genetic study by scientists from Baylor College of Medicine, the University of Oxford, the University of Wisconsin-Madison, and Bayer AG has uncovered the specific gene associated with the disorder. They found neuropeptide S receptor 1 (NPSR1). The researchers inhibited NPRS1 in their mouse models with the use of SHA 68R, a small molecular inhibitor. It reduced the abnormal growth of endometrial tissue outside of the uterus which led to reducing inflammation, pain, and endometriosis.
The team of researchers sequenced the DNA of 32 families in which more than three women have endometriosis. Cross-referencing the data led the researchers to discover that women with more severe cases of the disease had variants of the NPSR1 gene. SHA 68R is a small molecular structure known to inhibit NSPR1’s expressions
The animal studies done to inhibit NPSR1 from activating were completed by injecting a small solution with SHA 68R. It has promising results as a gene inhibitor. Researchers have stated an excitement to continue their study in genome sequencing. Jeffrey Rogers, Ph.D. and associate professor at the Human Genome Sequencing Center at Baylor, states “This is one of the first examples of DNA sequencing in nonhuman primates to validate results in human studies.”
With future studies, SHA 68R and other NPSR1 inhibitors may make their way to the medical field as nonhormonal and noninvasive treatment options for endometriosis.