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New Blood Test To Help Customize Treatment For Ovarian Cancer Patients

February 12, 2015 by Dr. Lori Gore-Green

Dr. Lori Gore-GreenResearchers have developed a new blood test that would allow doctors to anticipate how individual patients will respond to different types of treatment for ovarian cancer. Zeenews reports that the newly developed test can determine how combinations of certain proteins affect how the disease manifests in the body.

According to Gordon Jayson, a professor from the University of Manchester in Britain, the research has made strides in personalizing treatment for a type of cancer that is notoriously difficult to treat.

“We are keen to identify predictive bio-markers – measures that can indicate how well a patient will respond to treatment – so we can better target these drugs to patients most likely to benefit,” Jayson said.

In particular, the test can predict which patients may benefit from blood vessel targeting drugs like Bevacizumab. Two proteins are of particular interest — Ang1 and Tie2 —  in determining whether or not Bevacizumab would be effective when paired with traditional treatment. The two proteins are instrumental in controlling the creation of new blood vessels. Patients who had high levels of Ang1 but low levels of Tie2 were very likely to respond to the drug, while people with high levels of both proteins were unlikely to benefit.

The study, whose findings were published in the journal Clinical Cancer Research, took samples from ovarian cancer patients who were involved in an international trial for Bevacizumab. Candidates were either given the drug alongside their chemotherapy or were given chemotherapy alone.

The blood test still requires more development and testing, but this preliminary data is heartening. Researchers hope that the test will be available for you use by doctors and hospitals within the next few years.

Head over to Zeenews to read the original article.

Filed Under: Dr. Lori Gore-Green Tagged With: blood test, Ovarian Cancer, treatment

New Clinic Works To Improve Early Detection For Ovarian Cancer

January 7, 2015 by Dr. Lori Gore-Green

Dr. Lori Gore-GreenEarly diagnosis is among the biggest challenges in the fight against ovarian cancer. The lack of any reliable method of screening for the cancer often prevents it from being found its early stages. However, a recent article in the Miami Herald describes some of the efforts to develop early detection techniques.

At the University of Miami’s Sylvester Comprehensive Cancer Center in Miami  has opened a new Ovarian Cancer Early Detection Clinic. The aim of the new clinic is to identify women who are at a high risk for ovarian cancer by tracking family personal cancer histories. The hope is that by tracking the data gathered through patients that come through the clinic, that new preventive strategies can be derived.

One of the patients at the clinic, Ivanna Vidal, has the BRCA2 gene which put her at greater risk for ovarian and breast cancers. She was diagnosed with advanced stage ovarian cancer. The goal of the new clinic is to help at-risk women like Vidal learn of their risk factors earlier so that they might be able to better plan to preempt the disease.

The director of the gynecologic oncology division at Sylvester, Dr. Brian Slomovitz, states that women who have BRCA have a 20-40% chance of developing ovarian cancer. Talia Donenberg, senior cancer genetics counselor at the University of Miami and Jackson Memorial Hospital claims that the discovery of new genetic links to the disease has caused the rate of hereditary ovarian cancer to jump from 10% to between 15 and 20%.

This data and the fact that there are symptoms of ovarian cancer have made doctors and researchers hopeful that new early detection methods are not too far off.

“In the past, we thought it was a silent disease.” Slomovitz said, “We know now that that’s not the case.”

Read more at the Miami Herald.

Filed Under: Dr. Lori Gore-Green Tagged With: Clinic, Early Detection, Ovarian Cancer, Sylvester Comprehensive Cancer Center, University of Miami

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